Efecto de la sobre-expresión de DNMT3B en la actividad transcripcional de genes relacionados con el cáncer
Abstract
Abnormal methylation of promoters of genes suppressors of tumor and repairers of DNA is an epigenetic process that leads to its transcriptional silencing and is also a common event observed in cancer. DNMT3B is a DNA methyltransferase that is overexpressed in several types of cancer and primary tumors and it is responsible for the abnormal methylation of cancer-related genes. Although 5 genes are known as targets of DNMT3B, the elements that explain site-specific methylation are currently in the process of being explained
Abstract
La metilación anormal de promotores de genes supresores de tumor y reparadores de DNA es un proceso epigenético que lleva a su silenciamiento transcripcional y es además un evento común observado en cáncer. DNMT3B es una DNA metiltransferasa que se encuentra sobre-expresado en varios tipos de cáncer y tumores primarios y es responsable de la metilación anormal de genes relacionados con cáncer
Collections
- Artículos [67]
Visor XML
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-nd/4