Efecto del resveratrol sobre el nivel de expresión de los transportadores de glucosa GLUT en isquemia cerebral in vivo

Abstract

Ischemic stroke results from occlusion of a major cerebral artery and involves a cascade of metabolic events that begin during insult and proceed well into the blood flow recovery period [reperfusion (R)]. Impairment of cerebral blood flow restricts the delivery of substrates, predominantly oxygen and glucose with the consequent decline in the metabolism of energy and induction of glutamate excitotoxicity. Antioxidants [e.g. resveratrol (RSV)] prevent the ischemic-induced damage by increasing mitochondrial function through mechanisms closely associated with glucose metabolism