Expresión de p16INK4a, MCM2/TOPII y REST y estado físico del VPH 16 en el seguimiento de lesiones tempranas del cérvix uterino en mujeres guerrerenses
Resumen
In Mexico, invasive cervical carcinoma (ICC) remains the second most frequent carcinoma in women [1]. Persistent High-Risk HPV infection (HR-HPV) is the main risk factor for cervical carcinogenesis [2]. The viral infection is characterized cytologically by the presence of coilocytes that includes karyomegaly, binucleation, perinuclear halo and hyperchromasia among other cytological alterations. Bethesda cytological nomenclature uses these characteristics to classify pre-cancerosus lesions as lowgrade squamous intraepithelial lesion (LSIL) and high-grade (HSIL)
Resumen
The persistent infection of HPV16 and its DNA integration increase the risk of precancerous lesions progression to invasive cervical carcinoma (ICC) due to viral oncoproteins E6 and E7 overexpression, which are determinants for the malignant phenotype. Nevertheless, not all Low-Squamous Intraepitelial Lesions (LSIL) showing viral DNA integration are able to progress to High-Squamous Intraepitelial Lesions (HSIL) or carcinomes, indicating other factors are necessary for cell transformation
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