Expresión de p16INK4a, MCM2/TOPII y REST y estado físico del VPH 16 en el seguimiento de lesiones tempranas del cérvix uterino en mujeres guerrerenses

Castro Mora, Wendy Aide

dc.contributor	Alarcón Romero, Luz Del Carmen
dc.contributor.advisor	Alarcón Romero, Luz del Carmen; 259901
dc.contributor.author	Castro Mora, Wendy Aide
dc.creator	Castro Mora, Wendy Aide; 778715
dc.date.accessioned	2019-04-03T22:35:25Z
dc.date.available	2019-04-03T22:35:25Z
dc.date.issued	2019-01
dc.identifier.uri	http://ri.uagro.mx/handle/uagro/328
dc.description	The persistent infection of HPV16 and its DNA integration increase the risk of precancerous lesions progression to invasive cervical carcinoma (ICC) due to viral oncoproteins E6 and E7 overexpression, which are determinants for the malignant phenotype. Nevertheless, not all Low-Squamous Intraepitelial Lesions (LSIL) showing viral DNA integration are able to progress to High-Squamous Intraepitelial Lesions (HSIL) or carcinomes, indicating other factors are necessary for cell transformation
dc.description.abstract	In Mexico, invasive cervical carcinoma (ICC) remains the second most frequent carcinoma in women [1]. Persistent High-Risk HPV infection (HR-HPV) is the main risk factor for cervical carcinogenesis [2]. The viral infection is characterized cytologically by the presence of coilocytes that includes karyomegaly, binucleation, perinuclear halo and hyperchromasia among other cytological alterations. Bethesda cytological nomenclature uses these characteristics to classify pre-cancerosus lesions as lowgrade squamous intraepithelial lesion (LSIL) and high-grade (HSIL)
dc.description.sponsorship	Consejo Nacional de Ciencia y Tecnología (CONACYT)
dc.format	pdf
dc.language.iso	eng
dc.publisher	Universidad Autónoma de Guerrero (México)
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4
dc.subject	Tesauro Descriptores en Ciencias de la Salud /Viral integration
dc.subject	Tesauro Descriptores en Ciencias de la Salud /Human Papilloma Virus
dc.subject.classification	BIOLOGÍA Y QUÍMICA::QUÍMICA
dc.title	Expresión de p16INK4a, MCM2/TOPII y REST y estado físico del VPH 16 en el seguimiento de lesiones tempranas del cérvix uterino en mujeres guerrerenses
dc.type	Tesis de maestría
dc.contributor.committeeMember	Ortuño Pineda, Carlos
dc.contributor.committeeMember	Flores Alfaro, Eugenia
dc.contributor.committeeMember	Vences Velázquez, Amalia
dc.contributor.committeeMember	Guzmán Guzmán, Iris Paola
dc.contributor.committeeMember	Pereira Suarez, Ana Laura
dc.type.conacyt	masterThesis
dc.rights.acces	openAccess
dc.audience	generalPublic
dc.identificator	2\|\|23
dc.format.digitalOrigin	Born digital
dc.thesis.degreelevel	Maestria
dc.thesis.degreename	Maestría en Ciencias Biomédicas
dc.thesis.degreegrantor	Universidad Autónoma de Guerrero
dc.thesis.degreedepartment	Facultad de Ciencias Químico Biológicas
dc.thesis.degreediscipline	Biología y Química
dc.identifier.cvuagro	06291596
dc.viewer.xml	http://ri.uagro.mx:8081/viewer/index.php?code=06291596