Polimorfismos en los genes APOE y LDLR y su relación con el síndrome metabólico en mujeres guerrerenses
Resumen
The Dyslipidemia are the major risk factors in the development of coronary heart disease (CHD gene-environment and gene-gene interactions have been involved. Apolipoprotein E (ApoE) and the receptor for low density lipoproteins (LDLR) contribute to the lipoproteins excretion by the liver, thus reducing the cholesterol, triglycerides (TG) and lipoproteins levels. Three ApoE isoforms have been identified; the ApoE4 with cardiovascular disease, diabetes and elevated cholesterol, low density lipoprotein cholesterol (LDL-c) and TG
Resumen
Coronary heart disease (CHD) is the most common disease among cardiovascular diseases in developing countries, and the major cause of death in men and women around the world. CHD is multifactorial, involving both genetic and environmental factors as well as its possible interactions. The main cause of CHD is atherosclerosis, defined as a disease of blood vessels that involves degenerative and regenerative processes that affect the intimate initially, and the middle layer of the arteries in a later stage, mainly due to infiltration and deposition of lipid on the walls of the arteries
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