Polimorfismos en el gen de la Dihidrofolato Reductasa y respuesta al Metotrexato en Leucemia Linfoblástica aguda en México

Gómez Gómez, Yazmin

dc.contributor	Leyva Vázquez, Marco Antonio
dc.contributor.advisor	Leyva Vázquez, Marco Antonio; 264272
dc.contributor.author	Gómez Gómez, Yazmin
dc.creator	Gómez Gómez, Yazmin; 236728
dc.date.accessioned	2019-03-28T00:53:18Z
dc.date.available	2019-03-28T00:53:18Z
dc.date.issued	2009-08
dc.identifier.uri	http://ri.uagro.mx/handle/uagro/255
dc.description	Acute lymphoblastic leukemia (ALL) is a hematologic neoplasia characterized by clonal proliferation of immature lymphoid cells, the result of the malignant transformation of a lymphoid progenitor cell. In Mexico, acute leukemia is considering a problem of public health, it represents the fourth position of mortality of all neoplasic malignancies in children younger than fifteen years. In 2005, leukemia was the second cause of mortality in state of Guerrero in children younger than fifteen years, according to Institute National of Statistics Geography and Computing.
dc.description.abstract	The presence of polymorphisms in regulatory regions causes increased expression of dihydrofolate reductase (DHFR), and it is associated with methotrexate (MTX) treatment adverse events. A case control study was conducted on 70 children with acute lymphoblastic leukemia (ALL) and 140 children without disease.
dc.description.sponsorship	Consejo Nacional de Ciencia y Tecnología (CONACYT)
dc.format	pdf
dc.language.iso	eng
dc.publisher	Universidad Autónoma de Guerrero (México)
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4
dc.subject	Tesauro Descriptores en Ciencias de la Salud /Acute lymphoblastic leukemia
dc.subject	Tesauro Descriptores en Ciencias de la Salud /Dihydrofolate reductase
dc.subject	Tesauro Descriptores en Ciencias de la Salud /Single nucleotide polymorphism
dc.subject	Tesauro Descriptores en Ciencias de la Salud /Polymorphism
dc.subject.classification	MEDICINA Y CIENCIAS DE LA SALUD::CIENCIAS MÉDICAS
dc.title	Polimorfismos en el gen de la Dihidrofolato Reductasa y respuesta al Metotrexato en Leucemia Linfoblástica aguda en México
dc.type	Tesis de maestría
dc.contributor.committeeMember	Illades Aguilar, Berenice
dc.contributor.committeeMember	Moreno Godínez, Elena
dc.type.conacyt	masterThesis
dc.rights.acces	openAccess
dc.audience	generalPublic
dc.identificator	3\|\|32
dc.format.digitalOrigin	Born digital
dc.thesis.degreelevel	Maestria
dc.thesis.degreename	Maestría en Ciencias Biomédicas
dc.thesis.degreegrantor	Universidad Autónoma de Guerrero
dc.thesis.degreedepartment	Facultad de Ciencias Químico Biológicas
dc.thesis.degreediscipline	Medicina y Ciencias de la Salud
dc.identifier.cvuagro	07285978
dc.viewer.xml	http://ri.uagro.mx:8081/viewer/index.php?code=07285978