Efecto del extracto de ajo envejecido sobre el nivel de especies reactivas de oxígeno y fosforilación de la AMPK en un modelo in vivo de diabetes

Abstract

Hyperglycemia in diabetes is associated with long-term damage and dysfunction of organs such as eyes, kidney and heart. Hyperglycemia generates an increase in the production of reactive oxygen species and a decrease in endogenous antioxidants, generating oxidative stress. The oxidative stress damages lipids, carbohydrates, proteins and DNA, and decreases the activation of signaling pathways involved in glucose regulation, such as the insulin and AMPK pathways.