Polimorfismos en el gen de la y-glutamil hidrolasa y respuesta al metotrexato en leucemia linfoblástica aguda en México

Abstract

This study evaluated the association of -401C/T and +452C/T polymorphisms of y-glutamyl hydrolase and the lack of response to methotrexate in acute lymphoblastic leukemia. Genotyping was performed 70 children with acute lymphoblastic leukemia and 140 without. Association between -401C/T polymorphism and lack of response was found (p=0.028), patients with -401T/T genotype have 10.83 (CI95 1.30-90.14) more chance for a relapse of leukemia. No association was found between the +452C/T polymorphism and the response. Therefore, our investigation suggests that the -401C/T polymorphism in the y-glutamyl hydrolase may be a factor that would generate this lack of response to methotrexate in patients with ALL while the +452C/T cannot