Efecto de las variantes comunes en los genes SLC22A1 y SLC22A2 sobre el control glicémico de pacientes con diabetes tipo 2 tratados con metformina

Abstract

The organic cation transporters (OCT1 and OCT2) and the multidrug and toxin extrusiontransporter 1 (MATE1), encoded by the SLC22A1, SLC22A2, and SLC47A1 genes, respectively, are responsible for the absorption of the metformin in enterocytes, hepatocytes, and kidney cells. The aim of the study was to evaluate whether a genetic variation in the SLC22A1, SLC22A2, and SLC47A1 genes could be associated with an altered response to metformin in patients with type-2 diabetes (T2D). A cohort study was conducted in 308 individuals with a diagnosis of T2D of less than 3 years and who had metformin monotherapy